Hitoshi Hashimoto Selected Research

Pituitary Adenylate Cyclase-Activating Polypeptide Receptors

4/2020	Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice.
7/2006	New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice.
11/2004	PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

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Hitoshi Hashimoto Research Topics

Disease

18	Schizophrenia (Dementia Praecox) 03/2024 - 02/2008
11	Autistic Disorder (Autism) 03/2024 - 05/2013
11	Mental Disorders (Mental Disorder) 01/2019 - 01/2012
9	Autism Spectrum Disorder 01/2023 - 06/2015
8	Inflammation (Inflammations) 10/2019 - 07/2008
6	Cognitive Dysfunction 03/2024 - 02/2008
6	Neoplasms (Cancer) 01/2023 - 02/2014
6	Ischemia 06/2016 - 05/2006
5	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 11/2023 - 11/2003
5	Body Weight (Weight, Body) 04/2020 - 12/2004
5	Edema (Dropsy) 09/2015 - 08/2009
4	Hyperplasia 07/2015 - 05/2004
3	Treatment-Resistant Schizophrenia 01/2024 - 01/2017
3	Neurodevelopmental Disorders 11/2023 - 01/2017
3	Wounds and Injuries (Trauma) 04/2017 - 11/2010
3	AIDS-Related Complex (ARC) 01/2017 - 11/2004
3	Insulin Resistance 01/2016 - 05/2008
3	Hyperinsulinism (Hyperinsulinemia) 07/2015 - 05/2004
3	Pain (Aches) 10/2014 - 08/2004
3	Hyperalgesia 10/2014 - 08/2004
3	Hypothermia 01/2014 - 01/2010
2	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 02/2016
2	Epilepsy (Aura) 03/2024 - 09/2015
2	Anhedonia 02/2024 - 01/2020
2	Genetic Predisposition to Disease (Genetic Predisposition) 10/2022 - 01/2017
2	Parkinsonian Disorders (Parkinsonism) 01/2021 - 01/2018
2	Intellectual Disability (Idiocy) 01/2020 - 03/2004
2	Major Depressive Disorder (Major Depressive Disorders) 08/2017 - 01/2010
2	Weight Gain 04/2017 - 12/2004
2	Hypersensitivity (Allergy) 01/2016 - 11/2010
2	Spinal Cord Injuries (Spinal Cord Injury) 02/2015 - 11/2012
2	Brain Ischemia (Cerebral Ischemia) 09/2012 - 01/2010
2	Reperfusion Injury 09/2012 - 04/2011
2	Pancreatitis 01/2011 - 08/2009
2	Infarction (Infarctions) 01/2010 - 05/2006
2	Obesity 05/2008 - 05/2004
1	Breast Neoplasms (Breast Cancer) 01/2023
1	Neuroinflammatory Diseases 01/2023
1	Experimental Melanoma 01/2023
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 12/2021
1	Catalepsy 01/2021
1	Infections 04/2020
1	Hearing Loss (Hearing Impairment) 10/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Amyloid Plaque 01/2018

Drug/Important Bio-Agent (IBA)

53	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 11/2023 - 11/2003
7	Valproic Acid (Depakote)FDA LinkGeneric 01/2019 - 11/2014
6	Antipsychotic Agents (Antipsychotics)IBA 01/2024 - 11/2012
6	Messenger RNA (mRNA)IBA 01/2023 - 03/2004
5	Clozapine (Clozaril)FDA LinkGeneric 01/2024 - 11/2012
5	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2009
5	NeuropeptidesIBA 01/2019 - 06/2010
4	CorticosteroneIBA 01/2016 - 02/2013
4	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 05/2008
4	Capsaicin (Zostrix)FDA Link 09/2015 - 07/2011
3	Type II Vasoactive Intestinal Peptide ReceptorsIBA 01/2023 - 01/2018
3	Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 04/2020 - 11/2004
3	Ethanol (Ethyl Alcohol)IBA 11/2017 - 07/2006
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2016 - 08/2004
3	Insulin (Novolin)FDA Link 01/2016 - 05/2008
2	Ketamine FDA LinkGeneric 02/2024 - 02/2024
2	6-hydroxynorketamineIBA 02/2024 - 01/2020
2	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 11/2023 - 01/2016
2	Arachidonic Acid (Vitamin F)IBA 01/2023 - 09/2012
2	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 01/2023 - 06/2015
2	Retinaldehyde (Retinal)IBA 12/2021 - 01/2011
2	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 01/2016
2	Oxytocin (Pitocin)FDA LinkGeneric 01/2021 - 11/2017
2	LipidsIBA 01/2018 - 05/2008
2	Serotonin (5 Hydroxytryptamine)IBA 08/2017 - 11/2012
2	Dizocilpine Maleate (Dizocilpine)IBA 11/2016 - 11/2016
2	N-Methylaspartate (NMDA)IBA 11/2016 - 08/2004
2	EnzymesIBA 11/2016 - 01/2011
2	Galantamine (Galanthamine)FDA LinkGeneric 02/2016 - 02/2008
2	Donepezil (Aricept)FDA LinkGeneric 02/2016 - 02/2008
2	Neurotransmitter Agents (Neurotransmitter)IBA 08/2015 - 10/2014
2	ramatrobanIBA 05/2015 - 02/2014
2	LipopolysaccharidesIBA 05/2015 - 02/2014
2	MGS 0028IBA 02/2013 - 01/2012
2	Glutamic Acid (Glutamate)FDA Link 02/2013 - 01/2012
2	CytokinesIBA 04/2011 - 07/2008
2	CeruletideIBA 01/2011 - 08/2009
2	Interleukin-6 (Interleukin 6)IBA 07/2008 - 05/2006
1	Lactic Acid (Lactate)FDA LinkGeneric 03/2024
1	norketamineIBA 02/2024
1	Liposomes (Liposome)IBA 01/2023
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2023
1	Caspase 3 (Caspase-3)IBA 01/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2023
1	U 0126 (UO 126)IBA 01/2023
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2022
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022
1	phosphoinositide-3,4,5-triphosphateIBA 01/2022
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 10/2021
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2021
1	DNA Transposable Elements (Element, IS)IBA 01/2020
1	Protein Kinase D2IBA 11/2019
1	Angiogenic ProteinsIBA 10/2019
1	Amyloidogenic ProteinsIBA 01/2018

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2024